Publications

No. Publications 2017
152 Buttó LF, Haller D. Buchbeitrag zu "Crohn´s Disease and Ulcerative Colitis (Second Edition, 2017, Editor: Baumgart Daniel C.): Intestinal Microbiology and Ecology in Crohn´s Disease and Ulcerative Colitis. Springer International Publishing; ISBN 978-3-319-33701-2
151 Buttó LF, Haller D. Functional relevance of microbiome signatures: The correlation era requires tools for consolidation. J Allergy Clin Immunol. 2017 Apr;139(4):1092-1098. doi: 10.1016/j.jaci.2017.02.010. pubmed
150 Buttó LF, Haller D. Dysbiosis in Crohn's disease - Joint action of stochastic injuries and focal inflammation in the gut. Gut Microbes. 2017 Jan 2;8(1):53-58. doi: 10.1080/19490976.2016.1270810. Epub 2017 Jan 19. pubmed
No. Publications 2016
149 Kübeck R, Bonet-Ripoll C, Hoffmann C, Walker A, Müller VM, Schüppel VL, Lagkouvardos I, Scholz B, Engel KH, Daniel H, Schmitt-Kopplin P, Haller D, Clavel T, Klingenspor M. Dietary fat and gut microbiota interactions determine diet-induced obesity in mice. Mol Metab. 2016 Oct 13;5(12):1162-1174. eCollection 2016 Dec. pubmed
148 Lagkouvardos I, Pukall R, Abt B, Foesel BU, Meier-Kolthoff JP, Kumar N, Bresciani A, Martínez I, Just S, Ziegler C, Brugiroux S, Garzetti D, Wenning M, Bui TP, Wang J, Hugenholtz F, Plugge CM, Peterson DA, Hornef MW, Baines JF, Smidt H, Walter J, Kristiansen K, Nielsen HB, Haller D, Overmann J, Stecher B, Clavel T. Corrigendum: The Mouse Intestinal Bacterial Collection (miBC) provides host-specific insight into cultured diversity and functional potential of the gut microbiota. Nat Microbiol. 2016 Oct 17;1(11):16219. doi: 10.1038/nmicrobiol.2016.219. pubmed
147 Berger E, Rath E, Yuan D, Waldschmitt N, Khaloian S, Allgäuer M, Staszewski O, Lobner EM, Schöttl T, Giesbertz P, Coleman OI, Prinz M, Weber A, Gerhard M, Klingenspor M, Janssen K-P, Heikenwälder M, Haller D. Mitochondrial function controls intestinal epithelial stemness and Proliferation. Nat Commun. 2016 Oct 27;7:13171. doi: 10.1038/ncomms13171. pubmed
146 Lagkouvardos I, Pukall R, Abt B, Foesel BU, Meier-Kolthoff JP, Kumar N, Bresciani A, Martínez I, Just S, Ziegler C, Brugiroux S, Garzetti D, Wenning M, Bui TP, Wang J, Hugenholtz F, Plugge CM, Peterson DA, Hornef MW, Baines JF, Smidt H, Walter J, Kristiansen K, Nielsen HB, Haller D, Overmann J, Stecher B, Clavel T. The Mouse Intestinal Bacterial Collection (miBC) provides host-specific insight into cultured diversity and functional potential of the gut microbiota. Nat Microbiol. 2016 Aug 8;1(10):16131. doi: 10.1038/nmicrobiol.2016.131. pubmed
145 Lagkouvardos I, Joseph D, Kapfhammer M, Giritli S, Horn M, Haller D, Clavel T. IMNGS: A comprehensive open resource of processed 16S rRNA microbial profiles for ecology and diversity studies. Sci Rep. 2016 Sep 23;6:33721. doi: 10.1038/srep33721. pubmed
144 Endig J, Buitrago-Molina LE, Marhenke S, Reisinger F, Saborowski A, Schütt J, Limbourg F, Könecke C, Schreder A, Michael A, Misslitz AC, Healy ME, Geffers R, Clavel T, Haller D, Unger K, Finegold M, Weber A, Manns MP, Longerich T, Heikenwälder M, Vogel A. Dual Role of the Adaptive Immune System in Liver Injury and Hepatocellular Carcinoma Development. Cancer Cell. 2016 Aug 8;30(2):308-23. doi: 10.1016/j.ccell.2016.06.009. Epub 2016 Jul 28. pubmed
143 Hörmannsperger G, Blesl A, Haller D. Intestinales Mikrobiom. Aktuel. Ernährungsmed. 2016; 41:207-217
142 Schüppel V, Haller D. Das Mikrobiom bei chronischen Erkrankungen. Diabetologe DOI 10.1007/s11428-016-0124-3 published online 04 August 2016
141 Rausch P, Basic M, Batra A, Bischoff SC, Blaut M, Clavel T, Gläsner J, Gopalakrishnan S, Grassl GA, Günther C, Haller D, Hirose M, Ibrahim S, Loh G, Mattner J, Nagel S, Pabst O, Schmidt F, Siegmund B, Strowig T, Volynets V, Wirtz S, Zeissig S, Zeissig Y, Bleich A, Baines JF. Analysis of factors contributing to variation in the C57BL/6J fecal microbiota across German animal facilities. Int J Med Microbiol. 2016 Aug;306(5):343-55. doi: 10.1016/j.ijmm.2016.03.004. Epub 2016 Mar 15. pubmed
140 Buttó LF, Haller D. Dysbiosis in intestinal inflammation: Cause or consequence. Int J Med Microbiol. 2016 Aug;306(5):302-9. doi: 10.1016/j.ijmm.2016.02.010. Epub 2016 Mar 4. pubmed
139 Schwerd T, Frivolt K, Clavel T, Lagkouvardos I, Katona G, Mayr D, Uhlig HH, Haller D, Koletzko S, Bufler P. Exclusive enteral nutrition in active pediatric Crohn disease: Effects on intestinal microbiota and immune regulation. J Allergy Clin Immunol. 2016 Aug;138(2):592-6. doi: 10.1016/j.jaci.2015.12.1331. Epub 2016 Mar 15. [Epub ahead of print] pubmed
138 Frick JS, Haller D. Intestinal microbiota: From sequencing to function. Int J Med Microbiol. 2016 Aug;306(5):255-6. doi: 10.1016/j.ijmm.2016.02.007. Epub 2016 Feb 21. pubmed
137 Müller VM, Zietek T, Rohm F, Fiamoncini J, Lagkouvardos I, Haller D, Clavel T, Daniel H. Gut barrier impairment by high-fat diet in mice depends on housing conditions. Mol Nutr Food Res. 2016 Apr;60(4):897-908. doi: 10.1002/mnfr.201500775. Epub 2016 Jan 21. pubmed
136 Lee T, Clavel T, Smirnov K, Schmidt A, Lagkouvardos I, Walker A, Lucio M, Michalke B, Schmitt-Kopplin P, Fedorak R, Haller D. Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut. 2016 Feb 4. pii: gutjnl-2015-309940. doi: 10.1136/gutjnl-2015-309940. [Epub ahead of print] pubmed
No. Publications 2015
135 Haller D., Hörmannsperger G. Fachbuch „Darmgesundheit und Mikrobiota“. Springer-Verlag Berlin Heidelberg, 2015, www.springer.com/medicine/internal/book/978-3-658-07647-4
134 Hörmannsperger G., Haller D. Fachbuch „Entzündliche Darmerkrankungen“, Kapitel „Mikrobiologie“. Schattauer-Verlag Stuttgart, 2015, ISBN: 978-3-7945-3081-6
133 Buttó LF, Schaubeck M, Haller D. Mechanisms of Microbe-Host Interaction in Crohn's Disease: Dysbiosis vs. Pathobiont Selection. Front Immunol. 2015 Nov 19;6:555. doi: 10.3389/fimmu.2015.00555. eCollection 2015. pubmed
132 Zietek T, Rath E, Haller D, Daniel H. Intestinal organoids for assessing nutrient transport, sensing and incretin secretion. Sci Rep. 2015 Nov 19;5:16831. doi: 10.1038/srep16831. pubmed
131 Schaubeck M, Haller D. Reciprocal interaction of diet and microbiome in inflammatory bowel diseases. Curr Opin Gastroenterol. 2015 Nov;31(6):464-70. doi: 10.1097/MOG.0000000000000216. pubmed
130 Gruber L, Hemmerling J, Schüppel V, Müller M, Boekschoten MV, Haller D. Maternal High-fat Diet Accelerates Development of Crohn's Disease-like Ileitis in TNF?ARE/WT Offspring. Inflamm Bowel Dis. 2015 Sep;21(9):2016-25. doi: 10.1097/MIB.0000000000000465. pubmed
129 Hörmannsperger G, Schaubeck M, Haller D. Intestinal Microbiota in Animal Models of Inflammatory Diseases. ILAR J. 2015 Aug 31;56(2):179-91. doi: 10.1093/ilar/ilv019. pubmed
128 Ocvirk S, Sava IG, Lengfelder I, Lagkouvardos I, Steck N, Roh JH, Tchaptchet S, Bao Y, Hansen JJ, Huebner J, Carroll IM, Murray BE, Sartor RB, Haller D. Surface-Associated Lipoproteins Link Enterococcus faecalis Virulence to Colitogenic Activity in IL-10-Deficient Mice Independent of Their Expression Levels. PLoS Pathog. 2015 Jun 12;11(6):e1004911. doi: 10.1371/journal.ppat.1004911. eCollection 2015. pubmed
127 Lagkouvardos I, Kläring K, Heinzmann SS, Platz S, Scholz B, Engel K-H, Schmitt-Kopplin P, Haller D, Rohn S, Skurk T, Clavel T. Gut metabolites and bacterial community networks during a pilot intervention study with flaxseeds in healthy adult men. Mol Nutr Food Res. 2015 Aug;59(8):1614-28. doi: 10.1002/mnfr.201500125. Epub 2015 Jun 5. pubmed
126 Würth R, Lagkouvardos I, Clavel T, Wilke J, Foerst P, Kulozik U, Haller D, Hörmannsperger G. Physiological relevance of food grade microcapsules: Impact of milk protein based microcapsules on inflammation in mouse models for inflammatory bowel diseases. Mol Nutr Food Res. 2015 Aug;59(8):1629-34. doi: 10.1002/mnfr.201400885. Epub 2015 May 28. pubmed
125 Würth R, Hörmannsperger G, Wilke J, Foerst P, Haller D, Kulozik U. Protective effect of milk protein based microencapsulation on bacterial survival in simulated gastric juice versus the murine gastrointestinal system. Journal of Functional Foods, Volume 15, May 2015, Pages 116-125
124 Schaubeck M, Clavel T, Calasan J, Lagkouvardos I, Haange SB, Jehmlich N, Basic M, Dupont A, Hornef M, Bergen MV, Bleich A, Haller D. Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence. Gut. 2016 Feb;65(2):225-37. doi: 10.1136/gutjnl-2015-309333. Epub 2015 Apr 17. pubmed
123 Martin FP, Lichti P, Bosco N, Brahmbhatt V, Oliveira M, Haller D, Benyacoub J. Metabolic phenotyping of an adoptive transfer mouse model of experimental colitis and impact of dietary fish oil intake. J Proteome Res. 2015 Apr 3;14(4):1911-9. doi: 10.1021/pr501299m. Epub 2015 Mar 9. pubmed
122 Kless C, Müller VM, Schüppel VL, Lichtenegger M, Rychlik M, Daniel H, Klingenspor M, Haller D. Diet-induced obesity causes metabolic impairment independent of alterations in gut barrier integrity. Mol Nutr Food Res. 2015 May;59(5):968-78. doi: 10.1002/mnfr.201400840. Epub 2015 Mar 20. pubmed
121 Haller D, Hörmannsperger G. Interaction between humans and intestinal bacteria as a determinant for intestinal health : Intestinal microbiome and inflammatory bowel diseases. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2015 Feb;58(2):159-65. doi: 10.1007/s00103-014-2095-0 [Article in German] pubmed
120 Fasolino I, Izzo AA, Clavel T, Romano B, Haller D, Borrelli F. Orally-administered allyl sulfides from garlic ameliorate murine colitis. Mol Nutr Food Res. 2015 Mar;59(3):434-42. doi: 10.1002/mnfr.201400347. Epub 2015 Jan 21 pubmed
119 Kläring K, Just S, Lagkouvardos I, Hanske L, Haller D, Blaut M, Wenning M, Clavel T. Murimonas intestini gen. nov., sp. nov., an acetate-producing bacterium of the family Lachnospiraceae isolated from the mouse gut. Int J Syst Evol Microbiol. 2015 Mar;65(Pt 3):870-8. doi: 10.1099/ijs.0.000030. Epub 2014 Dec 17 pubmed
118 Hemmerling J, Jansen J, Müller M, Haller D. Fetal gut laser microdissection in combination with RNA preamplification enables epithelial-specific transcriptional profiling. J Immunol Methods. 2015 Jan;416:189-92. doi: 10.1016/j.jim.2014.11.008. Epub 2014 Nov 24 pubmed
No. Publications 2014
117 Wolf MJ, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, Ringelhan M, Simonavicius N, Egger M, Wohlleber D, Lorentzen A, Einer C, Schulz S, Clavel T, Protzer U, Thiele C, Zischka H, Moch H, Tschöp M, Tumanov AV, Haller D, Unger K, Karin M, Kopf M, Knolle P, Weber A, Heikenwalder M. Metabolic Activation of Intrahepatic CD8(+) T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes. Cancer Cell. 2014 Oct 13;26(4):549-64. doi: 10.1016/j.ccell.2014.09.003. pubmed
116 Volceanov L, Herbst K, Biniossek M, Schilling O, Haller D, Nölke T, Subbarayal P, Rudel T, Zieger B, Häcker G. Septins Arrange F-Actin-Containing Fibers on the Chlamydia trachomatis Inclusion and Are Required for Normal Release of the Inclusion by Extrusion. MBio. 2014 Oct 7;5(5). pii: e01802-14. doi: 10.1128/mBio.01802-14. pubmed
115 Wüstner S, Mejías-Luque R, Koch MF, Rath E, Vieth M, Sieber SA, Haller D, Gerhard M. Helicobacter pylori gamma-glutamyltranspeptidase impairs T-lymphocyte function by compromising metabolic adaption through inhibition of cMyc and IRF4 expression. Cell Microbiol. 2015 Jan;17(1):51-61. doi: 10.1111/cmi.12335. Epub 2014 Aug 30 pubmed
114 Erben U, Loddenkemper C, Doerfel K, Spieckermann S, Haller D, Heimesaat MM, Zeitz M, Siegmund B, Kühl AA. A guide to histomorphological evaluation of intestinal inflammation in mouse models. Int J Clin Exp Pathol. 2014 Jul 15;7(8):4557-76. eCollection 2014. pubmed
113 Clavel T, Desmarchelier C, Haller D, Gérard P, Rohn S, Lepage P, Daniel H. Intestinal microbiota in metabolic diseases: From bacterial community structure and functions to species of pathophysiological relevance. Gut Microbes. 2014 Jul 1;5(4):544-51. doi: 10.4161/gmic.29331. Epub 2014 Jul 8 pubmed
112 Haller D. Der Darm als immunkompetentes Grenzflächenorgan. Allergo Journal, Springer Medizin, 2014/4
111 Waldschmitt N, Berger E, Rath E, Sartor RB, Weigmann B, Heikenwalder M, Gerhard M, Janssen KP, Haller D. C/EBP homologous protein inhibits tissue repair in response to gut injury and is inversely regulated with chronic inflammation. Mucosal Immunol. 2014 Nov;7(6):1452-66. doi: 10.1038/mi.2014.34. Epub 2014 May 21 pubmed
110 Hemmerling J, Heller K, Hörmannsperger G, Bazanella M, Clavel T, Kollias G, Haller D. Fetal exposure to maternal inflammation does not affect postnatal development of genetically-driven ileitis and colitis. PLoS One. 2014 May 21;9(5):e98237. doi: 10.1371/journal.pone.0098237. eCollection 2014 pubmed
109 Lindenstrauss AG, Ehrmann MA, Behr J, Landstorfer R, Haller D, Sartor RB, Vogel RF. Transcriptome analysis of Enterococcus faecalis toward its adaption to surviving in the mouse intestinal tract. Arch Microbiol. 2014 Jun;196(6):423-33. doi: 10.1007/s00203-014-0982-2. Epub 2014 Apr 4 pubmed
108 Wuensch T, Ullrich S, Schulz S, Chamaillard M, Schaltenberg N, Rath E, Goebel U, Sartor RB, Prager M, Büning C, Bugert P, Witt H, Haller D, Daniel H. Colonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation. Inflamm Bowel Dis. 2014 Apr;20(4):671-84. doi: 10.1097/01.MIB.0000443336.71488.08 pubmed
107 Gruber L, Haller D. Buchbeitrag zu "Metabolomics and Gut Microbiota in Nutrition and Disease": Role of the Gut Microbiota in Maintaining GI Health: Highlights on Inflammatory Bowel Disease. Springer Verlag London, Jan. 2014, Copyright Year 2015
No. Publications 2013
106 Hörmannsperger G, Schaubeck M, Haller D. Ernährung und Medizin 2013; Buchbeitrag: Heilen mit Darmbakterien? Das Potenzial mikrobieller Therapien; 28:110-112
105 Hörmannsperger G, Schaubeck M, Haller D. Ernährung und Medizin 2013; Buchbeitrag: Die Bedeutung des intestinalen Mikrobioms für die Gesundheit des Menschen; 28:105-109
104 Haller D. Ernährung und Medizin 2013; Editorial; 28:97
103 Gruber L, Kisling S, Lichti P, Martin FP, May S, Klingenspor M, Lichtenegger M, Rychlik M, Haller D. High fat diet accelerates pathogenesis of murine Crohn's disease-like ileitis independently of obesity. PLoS One. 2013 Aug 16;8(8):e71661. doi: 10.1371/journal.pone.0071661 pubmed
102 Reichardt F, Baudry C, Gruber L, Mazzuoli G, Moriez R, Scherling C, Kollmann P, Daniel H, Kiesling S, Haller D, Neunlist M, Schemann M. Properties of myenteric neurons and mucosal functions in the distal colon of diet-induced obese mice. J Physiol. 2013 Oct 15;591(Pt 20):5125-39. doi: 10.1113/jphysiol.2013.262733. Epub 2013 Aug 12 pubmed
101 Daniel H, Gholami AM, Berry D, Desmarchelier C, Hahne H, Loh G, Mondot S, Lepage P, Rothballer M, Walker A, Böhm C, Wenning M, Wagner M, Blaut M, Schmitt-Kopplin P, Kuster B, Haller D, Clavel T. High fat diet alters gut microbiota physiology in mice. ISME J. 2014 Feb;8(2):295-308. doi: 10.1038/ismej.2013.155. Epub 2013 Sep 12 pubmed
100 Hörmannsperger G, von Schillde MA, Haller D. Lactocepin as a protective microbial structure in the context of IBD. Gut Microbes. 2013 Mar-Apr;4(2):152-7. doi: 10.4161/gmic.23444. Epub 2013 Jan 18 pubmed
099 Kläring K, Hanske L, Bui N, Charrier C, Blaut M, Haller D, Plugge CM, Clavel T. Intestinimonas butyriciproducens gen. nov., sp. nov., a novel butyrate-producing bacterium from the mouse intestine. Int J Syst Evol Microbiol. 2013 Dec;63(Pt 12):4606-12. doi: 10.1099/ijs.0.051441-0. Epub 2013 Aug 5 pubmed
098 Bosco N, Brahmbhatt V, Oliveira M, Martin FP, Lichti P, Raymond F, Mansourian R, Metairon S, Pace-Asciak C, Bastic Schmid V, Rezzi S, Haller D, Benyacoub J. Effects of increase in fish oil intake on intestinal eicosanoids and inflammation in a mouse model of colitis. Lipids Health Dis. 2013 May 31;12(1):81 [Epub ahead of print] pubmed
097 Schlapschy M, Binder U, Boerger C, Theobald I, Wachinger K, Kisling S, Haller D and Skerra A. PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins. Protein Eng Des Sel. 2013 Aug;26(8):489-501. doi: 10.1093/protein/gzt023. Epub 2013 Jun 10 pubmed
096 Wuensch T, Schulz S, Ullrich S, Lill N, Stelzl T, Rubio-Aliaga I, Loh G, Chamaillard M, Haller D, Daniel H. The peptide transporter PEPT1 is expressed in distal colon in rodents and humans and contributes to water absorption. Am J Physiol Gastrointest Liver Physiol. 2013 Jul 1;305(1):G66-73. doi: 10.1152/ajpgi.00491.2012. Epub 2013 May 9 pubmed
095 Steck N, Mueller K, Schemann M, Haller D. Republished: Bacterial proteases in IBD and IBS. Postgrad Med J. 2013 Jan;89(1047):25-33. doi: 10.1136/postgradmedj-2011-300775rep. pubmed FACULTY OF 1000 MUST READ
094 Clavel T, Charrier C, Wenning M, Haller D. Parvibacter caecicola gen. nov., sp. nov., a new bacterium of the family Coriobacteriaceae isolated from the caecum of a mouse. Int J Syst Evol Microbiol. 2013 Jul;63(Pt 7):2642-8. doi: 10.1099/ijs.0.045344-0. Epub 2013 Jan 4 pubmed
093 Wagner SJ, Schmidt A, Effenberger MJP, Gruber L, Danier J, Haller D. Semi-synthetic diet ameliorates Crohn´s disease-like ileitis in TNF∆ARE/WT mice through antigen-independent mechanisms of gluten. Inflamm Bowel Dis. 2013 May;19(6):1285-94. doi: 10.1097/MIB.0b013e318281f573 pubmed
092 Calder PC, Ahluwalia N, Albers R, Bosco N, Bourdet-Sicard R, Haller D, Holgate ST, Jönsson LS, Latulippe ME, Marcos A, Moreines J, M´Rini C, Müller M, Pawelec G, van Neerven RJJ, Watzl B, Zhao J. A consideration of biomarkers to be used for evaluation of inflammation in human nutritional studies. Br J Nutr. 2013 Jan;109 Suppl 1:S1-34 pubmed
No. Publications 2012
091 Lindenstrauß AG, Behr J, Ehrmann MA, Haller D, Vogel RF. Identification of fitness determinants in Enterococcus faecalis by differential proteomics. Arch Microbiol. 2013 Feb;195(2):121-30. doi: 10.1007/s00203-012-0857-3. Epub 2012 Dec 13. pubmed
090 Clavel T, Charrier C, Haller D. Streptococcus danieliae sp. nov., a novel bacterium isolated from the caecum of a mouse. Arch Microbiol. 2013 Jan;195(1):43-9. doi: 10.1007/s00203-012-0846-6. Epub 2012 Oct 7. pubmed
089 Gruber L, Lichti P, Rath E, Haller D. Nutrigenomics and nutrigenetics in inflammatory bowel diseases. J Clin Gastroenterol. 2012 Oct;46(9):735-47. pubmed
088 Rath E, Haller D. Unfolded protein responses in the intestinal epithelium: sensors for the microbial and metabolic environment. J Clin Gastroenterol. 2012 Oct;46 Suppl:S3-5. pubmed
087 Chang J-S, Ocvirk S, Berger E, Kisling S, Binder U, Skerra A, Lee AS, Haller D. Endoplasmic reticulum stress response promotes cytotoxic phenotype of CD8αβ+ intraepithelial lymphocytes in a mouse model for Crohn´s disease-like ileitis. J Immunol. 2012 Aug 1;189(3):1510-20. pubmed
086 Pfeiffer N, Desmarchelier C, Blaut M, Daniel H, Haller D, Clavel T. Acetatifactor muris gen. nov., sp. nov., a novel bacterium isolated from the intestine of an obese mouse. Arch Microbiol. 2012 Jun 4. [Epub ahead of print] pubmed
085 Boeing H, Bechthold A, Bub A, Ellinger S, Haller D, Kroke A, Leschik-Bonnet E, Müller MJ, Oberritter H, Schulze M, Stehle P, Watzl B. Critical review: vegetables and fruit in the prevention of chronic diseases. Eur J Nutr. 2012 Sep;51(6):637-63. pubmed
084 Rath E, Haller D. PKR-signaling in DSS-induced colitis: Detrime-N-tal or prote-C-tive? Inflamm. Bowel Dis. 2012 Apr 16. doi: 10.1002/ibd.22975. [Epub ahead of print] pubmed
083 Von Schillde M-A, Hörmannsperger G, Weiher M, Alpert CA, Hahne H, Bäuerl C, van Huynegem K, Steidler L, Hrncir T, Pérez-Martínez G, Kuster B, Haller D. Lactocepin secreted by Lactobacillus exerts anti-inflammatory effects by selectively degrading pro-inflammatory chemokines. Cell Host Microbe. 2012 Apr 19;11(4):387-96 pubmed FACULTY OF 1000 MUST READ
082 Hörmannsperger G, Haller D. Prävention und Therapie von Erkrankungen - Probiotika: Anforderungen und Wirkmechanismen. Pharm. Unserer Zeit 2/2012(41).
081 Von Schillde M-A, Haller D. Multi-Spezies- und Designer-Probiotika - Probiotika: Quo Vadis...? Pharm. Unserer Zeit 2/2012(41).
080 Haller D. Der Darm als Grenzfläche zur Umwelt: Epithelzellen als Sensor und Signalgeber. Aktuel. Ernährungsmed. 2012;37, Supplement 1:S1-4.
079 Hoermannsperger G, Clavel T, Haller D. Gut matters: Microbe-host interactions in allergic diseases. J Allergy Clin Immunol. 2012 Jun;129(6):1452-9. pubmed
No. Publications 2011
078 Rath E, Haller D. Mitochondria at the interface between danger signaling and metabolism: Role of unfolded protein responses in chronic inflammation. Inflamm Bowel Dis. 2012 Jul;18(7):1364-77. doi: 10.1002/ibd.21944. Epub 2011 Dec 19.pubmed
077 Renz H, Autenrieth IB, Brandtzæg P, Cookson WO, Holgate S, von Mutius E, Valenta R, Haller D. Gene-environment interaction in chronic disease: A European Science Foundation Forward Look. J. Allergy Clin. Immunol. 2011 Dec;128(6 Suppl):S27-49. pubmed
076 Steck N, Mueller K, Schemann M, Haller D. Bacterial proteases in IBD and IBS. Gut. 2012 Nov;61(11):1610-8. Epub 2011 Sep 7. pubmed FACULTY OF 1000 MUST READ
075 Patterson AM, Delday MI, van Kuppevelt TH, Loh G, Blaut M, Haller D, Grant G, Kelly D. Expression of heparan sulphate proteoglycans in murine models of experimental colitis. Inflamm Bowel Dis. 2012 Jun;18(6):1112-26. doi: 10.1002/ibd.21879. Epub 2011 Oct 10. pubmed
074 Baur P, Martin F-P, Gruber L, Bosco N, Brahmbhatt V, Collino S, Guy P, Montoliu I, Rozman J, Klingenspor M, Tavazzi I, Thorimbert A, Rezzi S, Kochhar S, Benyacoub J, Kollias G, Haller D. Metabolic Phenotyping of the Crohn´s Disease-like IBD Etiopathology in the TNF∆ARE/WT Mouse Model. J. Proteome Res. 2011 Dec 2;10(12):5523-35. pubmed
073 Mapesa JO, Waldschmitt N, Schmöller I, Blume C, Hofmann T, Mahungu S, Clavel T, Haller D. Catechols in caffeic acid phenethyl ester are essential for inhibition of TNF-mediated IP-10 expression through NF-kB-dependent but HO-1- and p38-independent mechanisms in mouse intestinal epithelial cells. Mol. Nutr. Food Res. 2011, 55, 1-12 pubmed
072 Rath E, Berger E, Messlik A, Nunes T, Liu B, Kim SC, Hoogenraad N, Sans M, Sartor RB, Haller D. Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation. Gut 2012 Sep;61(9):1269-78. doi: 10.1136/gutjnl-2011-300767. Epub 2011 Oct 13. pubmed
071 Wohlgemuth S, Keller S, Kertscher R, Stadion M, Haller D, Kisling S, Jahreis G, Blaut M, Loh G. Intestinal steroid profiles and microbiota composition in colitic mice. Gut Microbes. 2011 May-Jun;2(3):159-66. pubmed
070 Berger E, Haller D. Structure-function analysis of the tertiary bile acid TUDCA for the resolution of endoplasmic reticulum stress in intestinal epithelial cells. Biochem Biophys Res Commun. 2011 Jun 17;409(4):610-5 pubmed
069 Steck N, Hoffmann M, Sava IG, Kim SC, Hahne H, Tonkonogy SL, Mair K, Krueger D, Pruteanu M, Shanahan F, Vogelmann R, Schemann M, Kuster B, Sartor RB and Haller D. Enterococcus faecalis Metalloprotease Compromises Epithelial Barrier and Contributes to Intestinal Inflammation. Gastroenterology 2011 Sep;141(3):959-71. pubmed FACULTY OF 1000 TOP 2% OF PUBLISHED ARTICLES
068 Rath E, Haller D. Inflammation and cellular stress: a mechanistic link between immune-mediated and metabolically driven pathologies. Eur. J. Nutr. 2011 Jun;50(4):219-33. pubmed
067 Renz H, von Mutius E, Brandtzaeg P, Cookson W, Autenrieth I, Haller D. Gene environment interaction in chronic inflammatory disease. Nat. Immunol. 2011 Apr 12(4):273-277 pubmed
066 Haller D. Author’s response: the irony about sulphate in experimental ileitis - iron is not over-rated. Gut 2012;61:324 (acceptet May 2011). Gut
065 Werner T, Wagner S, Martinez I, Walter J, Chang JS, Clavel T, Kisling S, Schuemann K, Haller D. Depletion of luminal iron alters the gut microbiota and prevents Crohn´s disease-like ileitis. Gut 2011 Mar;60(3):325-33 pubmed
064 Krinninger P, Brunner C, Ruiz PA, Schneider E, Marx N, Foryst-Ludwig A, Kintscher U, Haller D, Laumen H, Hauner H. Role of the adipocyte-specific NF-kB activity in the regulation of IP-10 and T cell migration. Am. J. Physiol. Endocrinol. Metab. 2011 Feb;300(2):E304-11 pubmed
063 Rogler G, Haller D, Jobin C. Microbiota in chronic mucosal inflammation. Int. J. Inflam. 2011 Jan 11;2010:395032 pubmed
062 Hoffmann M, Messlik A, Kim SC, Sartor RB, Haller D. Impact of a probiotic Enterococcus faecalis in a gnotobiotic mouse model of experimental colitis. Mol. Nutr. Food Res. 2011 May;55(5):703-13. pubmed
No. Publications 2010
061 Haller D, Autenrieth IB. Microbe-host interaction in chronic diseases. Int. J. Med. Microbiol. 2010 Jan;300(1):1-2 pubmed
060 Hörmannsperger G, Haller D. Molecular crosstalk of probiotic bacteria with the intestinal immune system: Clinical relevance in the context of inflammatory bowel disease. Int. J. Med. Microbiol. 2010 Jan;300(1):63-73 pubmed
059 Rijkers G T, Bengmark S, Enck P, Haller D, Herz U, Kalliomäki M, Kudo S, Lenoir-Wijnkoop I, Mercenier A, Myllyluoma E, Rabot S, Rafter J, Szajewska H, Watzl B, Wells J M, Wolvers D, Antoine J-M. Guidance for substantiating the evidence of the probiotics beneficial effects: Current status and recommendations for future research. J. Nutr. 2010 Mar;140(3):671S-6S pubmed
058 Haller D, Antoine J-M, Bengmark S, Enck P, Rijkers G T, Lenoir-Wijnkoop I. Guidance for substantiating the evidence of the probiotics beneficial effects: Probiotics in chronic inflammatory bowel disease (IBD) and the functional disorder, irritable bowel syndrome (IBS). J. Nutr. 2010 Mar;140(3):690S-7S pubmed
057 Diegelmann J, Seiderer J, Niess J-H, Haller D, Göke B, Reinecker H-Ch, Brand S. Expression and regulation of the chemokine CXCL16 in Crohn´s disease and models of intestinal inflammation. Inflamm. Bowel Dis. 2010 Nov;16(11):1871-81 pubmed
056 Haller D, Ekici P, Friess A, Parlar H. High enrichment of MMP-9 and carboxypeptidase A by tweezing adsorptive bubble separation (TABS). Appl. Biochem. Biotechnol. 2010 Nov;162(6):1547-57 pubmed
055 Hörmannsperger G, Clavel T, Hoffmann M, Reiff C, Kelly D, Loh G, Blaut M, Hölzlwimmer G, Haller D. Post-translational inhibition of proinflammatory chemokine secretion in intestinal epithelial cells: implications for specific IBD indications. J. Clin. Gastroenterol. 2010 Sep;44 Suppl 1:S10-5 pubmed
054 Haller D. Nutrigenomics and IBD: The intestinal microbiota at the cross-road between inflammation and metabolism. J. Clin. Gastroenterol. 2010 Sep;44 Suppl 1:S6-9 pubmed
053 Sanders ME, Akkermans LM, Haller D, Hammerman C, Heimbach J, Hörmannsperger G, Huys G, Levy DD, Lutgendorff F, Mack D, Phothirath P, Solano-Aguilar G, Vaughan E. Safety assessment of probiotics for human use. A Review. Gut Microbes 2010 May;1(3):164-185 pubmed
052 Clavel T, Saalfrank A, Charrier C, Haller D. Isolation of bacteria from mouse caecal samples and description of Bacteroides sartorii sp. nov. Arch. Microbiol. 2010 Jun;192(6):427-35 pubmed
051 Krane M, Dummler S, Dreßen M, Hauner H, Haller D, Heller K, Wildhirt S, Voss B, Grammer J, Lahm H, Lange R, Bauernschmitt R. Identification of an up-regulated anti-apoptotic network in the internal thoracic artery. Int. J. Cardiol. 2011 Jun 2;149(2):221-226. Epub 2010 Mar 6. pubmed
No. Publications 2009
050 Martin FP, Rezzi S, Philippe D, Tornier L, Messlik A, Hölzlwimmer G, Baur P, Quintanilla-Fend L, Loh G, Blaut M, Blum S, Kochhar S, Haller D. Metabolic Assessment of Gradual Development of Moderate Experimental Colitis in IL-10 Deficient Mice. J. Proteome Res. 2009 May 1;8(5):2376-87 pubmed
049 Hörmannsperger G, Clavel T, Hoffmann M, Reiff C, Kelly D, Loh G, Blaut M, Hölzlwimmer G, Laschinger M, Haller D. Post-translational inhibition of IP-10 secretion in IEC by probiotic bacteria: Impact on chronic inflammation. PLoS One 2009;4(2):e4365 pubmed
048 Wohlgemuth S, Haller D, Blaut M, Loh G. Reduced microbial diversity and high numbers of one single E. coli strain in the intestine of colitic mice. Environ. Microbiol. 2009 Jun;11(6):1562-71 pubmed
047 Hoffmann M, Kim SC, Sartor RB, Haller D. Enterococcus faecalis strains differentially regulate Alix/AIP1 protein expression and ERK 1/2 activation in intestinal epithelial cells in the context of chronic experimental colitis. J. Proteome Res. 2009 Mar;8(3):1183-92 pubmed
046 Clavel T, Charrier C, Braune A, Wenning M, Blaut M, Haller D. Isolation of bacteria from the ileal mucosa of TNFdeltaARE mice and description of Enterorhabdus mucosicola gen. nov., sp. nov. Int. J. Syst. Evol. Microbiol. 2009 Jul;59(Pt 7):1805-12 pubmed
045 Reiff C, Delday M, Rucklidge G, Reid M, Duncan G, Hörmannsperger G, Loh G, Blaut M, Collie-Duguid E, Haller D, Kelly D. Balancing inflammatory, lipid and xenobiotic signalling pathways by VSL#3, a biotherapeutic agent, in treating inflammatory bowel disease. Inflamm. Bowel Dis. 2009 Nov;15(11):1721-36 pubmed
044 Werner T, Hörmannsperger G, Schümann K, Hölzlwimmer G, Tsuji S, Haller D. Intestinal Epithelial Cell Proteome from wild type and TNF∆ARE/WT mice: effect of iron on the development of chronic ileitis. J. Proteome Res. 2009 Jul 6;8(7):3252-64 pubmed
043 Clavel T, Duck W, Charrier C, Wenning M, Elson C, Haller D. Enterorhabdus caecimuris sp. nov., a novel Coriobacteriaceae from a mouse model of spontaneous colitis. Int. J. Syst. Evol. Microbiol. 2010 Jul;60(Pt 7):1527-31. Epub 2009 Aug 14. pubmed
042 Messlik A, Schmechel S, Kisling S, Bereswill S, Heimesaat MM, Fischer A, Göbel U, Haller D. Loss of Toll-like receptor 2 and 4 leads to differnential induction of endoplasmic reticulum stress and proapoptotic responses in the intestinal epithelium under conditions of chronic inflammation. J. Proteome. Res. 2009 Oct;8(10):4406-17 pubmed
041 Haller D. Buchbeitrag in "Probiotika, Präbiotika und Synbiotika", Kapitel 4: Darmepithelzellen als interaktive Schnittstelle zwischen Bakterien und Immunsystem. Herausgeber Stephan Bischoff, ISBN 978-3-13-144891-0, Thieme Verlag 2009
040 Hörmannsperger G, Haller D. Probiotische Mechanismen im Kontext chronisch entzündlicher Darmerkrankungen. Deutsche Milchwirtschaft 16/2009 (60. Jg.)
039 Hörmannsperger G, Haller D. Probiotische Mechanismen im Kontext chronisch entzündlicher Darmerkrankungen. Bauchredner 3/2009
038 Haller D. Der Darm als integraler Bestandteil von Stoffwechsel und Immunfunktion. Begleitender Ausstellungskatalog Alimentarium Vevey, Schweiz
No. Publications 2008
037 Matthies A, Clavel T, Gütschow M, Engst W, Haller D, Blaut M, Braune A. Conversion of daidzein and genistein by an anaerobic bacterium newly isolated from the mouse intestine. Appl. Environ. Microbiol. 2008; Aug;74(15):4847-52 pubmed
036 Hoffmann M, Rath E, Hölzlwimmer G, Loach D, Tannock G, Haller D. Lactobacillus reuteri 100-23 transiently activates intestinal epithelial cells of mice that have a complex microbiota during early stages of colonization. J. Nutr. 2008; Sep;138(9):1684-91 pubmed
035 Glas J, Konrad A, Schmechel S, Dambacher J, Seiderer J, Schroff F, Wetzke M, Roeske D, Török HP, Tonenchi L, Pfennig S, Haller D, Griga T, Klein W, Epplen JT, Folwaczny C, Lohse P, Göke B, Ochsenkühn T, Mussack T, Folwaczny M, Müller-Myhsok B, Brand S. The ATG16L1 Gene Variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population. Am. J. Gastroenterol. 2008;103(3):682-691 pubmed
034 Haller D. Mehr als nur ein Bollwerk - das Darmepithel als integrativer Bestandteil der Barriere und Abwehrfunktion im Darm. Aktuel. Ernaehr. Med. 2008;33:S7-S10
033 Haller D. Molecular interactions of commensal enteric bacteria with the intestinal epithelium and the mucosal immune system. Bioscience & Microflora 2008;27(2)
No. Publications 2007
032 Werner T, Shkoda A, Haller D. Intestinal epithelial cell proteome in IL-10 deficient mice and IL-10 receptor reconstituted epithelial cells: impact on chronic inflammation. J. Proteome Res. 2007;6(9):3691-704 pubmed
031 Werner T, Haller D. Intestinal epithelial cell signalling and chronic inflammation: From the proteome to specific molecular mechanisms. Mutation Res. 2007;622(1-2):42-57 pubmed
030 Seiderer J, Dambacher J, Kuhnlein B, Pfennig S, Konrad A, Török HP, Haller D, Göke B, Ochsenkühn T, Lohse P, Brand S. The role of the selenoprotein S (SELS) gene -105G>A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation. Tissue Antigens 2007;70(3):238-46 pubmed
029 Dambacher J, Beigel F, Seiderer J, Haller D, Goke B, Auernhammer CJ, Brand S. Interleukin-31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is up-regulated in inflammatory bowel disease. Gut 2007;56(9):1257-65 pubmed
028 Clavel T and Haller D. Bacteria- and host-derived mechanisms to control intestinal epithelial cell homeostasis: implications for chronic inflammation. Inflamm. Bowel Dis. 2007;13(9):1153-64 pubmed
027 Clavel T and Haller D. Molecular interactions between bacteria, the epithelium and the mucosal immune system in the intestinal tract: Implications for chronic inflammation. Curr. Issues Intest. Microbiol. 2007;8(2):25-43 (rewiew) pubmed
026 Ruiz PA, Braune A, Hölzlwimmer G, Quintanilla-Fend L, Haller D. Quercetin inhibits TNF-induced transcription factor recruitment to pro-inflammatory gene promoters in murine intestinal epithelial cells. J. Nutr. 2007;137:1208-1215 pubmed
025 Shkoda A, Werner T, Daniel H, Gunckel M, Rogler G, Haller D. Differential protein expression profile in the intestinal epithelium from patients with inflammatory bowel disease. J. Proteome Res. 2007;6(3):1114-25 pubmed
024 Shkoda A, Ruiz PA, Daniel H, Kim SC, Rogler G, Sartor RB, Haller D. IL-10 blocked endoplasmatic reticulum stress in the intestinal epithelium: impact on chronic inflammation. Gastroenterology 2007;132:190-207 pubmed
No. Publications 2006
023 Ruiz PA, Shkoda A, Kim SC, Sartor RB, Haller D. IL-10 gene deficient mice lack TGF-ß/Smad-mediated TLR2 degradation and fail to inhibit pro-inflammatory gene expression in intestinal epithelial cells under conditions of chronic inflammation. Ann. NY Acad. Sci 2006;1072:389-394 pubmed
022 Ruiz PA and Haller D. Functional diversity of flavonoids in the inhibition of the pro-inflammatory NF-kB, IRF and Akt signaling pathways in murine intestinal epithelial cells. J. Nutr. 2006;136:664-671 pubmed
021 Haller D. Intestinal epithelial cell signaling and host-derived negative regulators under chronic inflammation: To be or not be activated determines the balance towards commensal bacteria. Neurogastroenterol. Motil. 2006;18:184-199 pubmed
No. Publications 2005
020 Ruiz PA, Hoffmann M, Sczesny S, Blaut M., Haller D. Innate mechanisms for Bifidobacterium lactis to activate transient pro-inflammatory host responses in intestinal epithelial cells after the colonization of germfree rats. Immunol. 2005;115:441-450 pubmed
019 Ruiz PA, Shkoda A, Kim SC, Sartor RB, Haller D. IL-10 gene deficient mice lack TGF-ß/Smad signaling and fail to inhibit pro-inflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis J. Immunol. 2005;174:2990-2999 pubmed
018 Haller D. Molecular interactions of commensal Enteric Bacteria with the Intestinal Epithelium and the Mucosal Immune System: Implications for Chronic Intestinal Inflammation. (Chapter 6). In: Tannock GW, ed. Probiotics and Prebiotics: Scientific aspects. Horizon Scientific Press 2005
No. Publications 2004
017 Parlesak A, Haller D, Brinz S, Bäuerlein A, Bode C. Modulation of cytokine release by differentiated CaCO-2 cells in a compartmentalized coculture model with mononuclear leukocytes and non-pathogenic bacteria. Scand. J. Immunol. 2004;60:477-485 pubmed
016 Ruiz PA, Kim SC, Sartor RB, Haller D. 15-deoxy-D12,14-prostaglandin J2-mediated ERK signaling inhibits Gram-negative bacteria-induced RelA phosphorylation and IL-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity. J. Biol. Chem. 2004;279:36103-36111 pubmed
015 Haller D, Holt L, Parlesak A, Zanga J, Bäuerlein A, Sartor RB, Jobin C. Differential effect of immune cells on non-pathogenic Gram-negative bacteria-induced NF-kB activation and pro-inflammatory gene expression in intestinal epithelial cells. Immunology 2004;112:310-320 pubmed
014 Haller D and Jobin C. Interaction between resident luminal bacteria and the host: Can a healthy relationship turn sour? J. Pediat. Gastro. Nutr. 2004;38:123-136 pubmed
No. Publications 2003
013 Haller D, Holt L, Kim SC, Schwabe RF, Sartor RB, Jobin C. TGF-ß1 inhibits non-pathogenic Gram-negative bacteria-induced NF-kB recruitment to the IL-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation. J. Biol. Chem. 2003;278:23851-23860 pubmed
No. Publications 2002
012 Haller D, Russo MP, Sartor RB, Jobin C. IKKß and PI3K/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kB activation in both primary and intestinal epithelial cell lines. J. Biol. Chem. 2002; 277:38168-38178 pubmed
011 Haller D, Serrant P, Granato D, Schiffrin EJ, Blum S. Activation of human NK cells by staphylococci and lactobacilli requires cell contact-dependent co-stimulation by autologous monocytes. Clin. Diag. Lab. Immunol. 2002;9:649-657 pubmed
010 Haller D, Serrant P, Peruisseau G, Bode C, Hammes WP, Schiffrin EJ, Blum S. IL-10 producing CD14low monocytes inhibit lymphocyte-dependent activation of intestinal epithelial cells by commensal bacteria. Microbiol. Immunol. 2002;46:195-205 pubmed
009 Blum S, Haller D, Pfeifer A, Schiffrin EJ. Probiotics and immune response. Clin. Rev. Allergy Immunol. 2002;22:287-309 pubmed
008 Haller D. and Sartor RB. Induction of tolerogenic versus pathogenic mucosal immune responses by commensal enteric bacteria. In: Morteau O, ed.Oral tolerance: The responses of the Intestinal Mucosa to Dietary Antigens. Georgetown: Landes Bioscience/Eurekah.com, 2002
007 Hammes WP, Haller D, Gänzle M. Fermented Meat. In: Farnthworth, ed. Fermented Functional Foods. Boca Raton: CRC Press LIC 2002
No. Publications 2001
006 Haller D, Colbus H, Gänzle M, Scherenbacher H, Bode C, Hammes WP. Metabolic and functional properties of lactic acid bacteria in the gastro-intestinal ecosystem: A comparative in vitro study between bacteria of intestinal and fermented food origin. Sys. Appl. Microbiol. 2001;24:218-226 pubmed
No. Publications 2000
005 Haller D, Bode C, Hammes WP, Pfeifer AMA, Schiffrin EJ, Blum S. Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leukocyte co-cultures. Gut 2000;47:79-87 pubmed
004 Haller D, Blum S, Bode C, Hammes WP, Schiffrin EJ. Activation of human peripheral blood mononuclear cells by nonpathogenic bacteria in vitro: evidence of NK cells as primary targets. Infect. Immun. 2000;68:752-759 pubmed
No. Publications 1999
003 Haller D, Bode C, Hammes WP. Cytokine secretion by stimulated monocytes depends on the growth phase and heat treatment of bacteria: a comparative study between lactic acid bacteria and invasive pathogens. Microbiol Immunol. 1999;43(10):925-35 pubmed
002 Blum S, Delneste Y, Alvarez S, Haller D, Perez PF, Bode Ch, Hammes WP, Pfeifer AMA, Schiffrin EJ. Interaction between commensal bacteria and mucosal immunocompetent cells. International Dairy Journal 1999;9:63-66
001 Blum S, Alvarez S, Haller D, Perez PF, Schiffrin EJ. Intestinal microflora and the interaction with immunocompetent cells. Antonie van Leeuwenhoek 1999;76: 199-205 pubmed